Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis

Item Type:	Article
Title:	Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis
Creators Name:	Hooper, S.D. and Boue, S. and Krause, R. and Jensen, L.J. and Mason, C.E. and Ghanim, M. and White, K.P. and Furlong, E.E. and Bork, P.
Abstract:	Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. By applying conservative filtering criteria and requiring 'sharp' transcript changes, we identified 1534 maternal genes, 792 transient zygotic genes, and 1053 genes whose transcript levels increase during embryogenesis. Each of these three categories is dominated by groups of genes where all transcript levels increase and/or decrease at similar times, suggesting a common mode of regulation. For example, 34% of the transiently expressed genes fall into three groups, with increased transcript levels between 2.5-12, 11-20, and 15-20 h of development, respectively. We highlight common and distinctive functional features of these expression groups and identify a coupling between downregulation of transcript levels and targeted protein degradation. By mapping the groups to the protein network, we also predict and experimentally confirm new functional associations.
Keywords:	Drosophila Embryogenesis, Notch Pathway, Supervised Clustering, Transient Expression, Animals
Source:	Molecular Systems Biology
ISSN:	1744-4292
Publisher:	Nature Publishing Group
Volume:	3
Page Range:	72
Date:	January 2007
Official Publication:	https://doi.org/10.1038/msb4100112
PubMed:	View item in PubMed

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