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They are not too excited: the possible role of adult-born neurons in epilepsy

Item Type:Editorial
Title:They are not too excited: the possible role of adult-born neurons in epilepsy
Creators Name:Kempermann, G.
Abstract:In a new study in this issue of Neuron, Jakubs and colleagues report that adult-generated hippocampal granule cells develop particular functional properties when their birth is induced by epileptic seizures. The new neurons showed reduced excitatory synaptic input and decreased excitability. Their functional integration was thus adjusted to the prevailing functional state in the network. By this means, adult neurogenesis might contribute to network homeostasis in the epileptic temporal lobe.
Keywords:Epilepsy, Hippocampus, Neurological Models, Neuronal Plasticity, Neurons, Animals
Source:Neuron
ISSN:0896-6273
Publisher:Cell Press (U.S.A.)
Volume:52
Number:6
Page Range:935-937
Date:21 December 2006
Official Publication:https://doi.org/10.1016/j.neuron.2006.12.004
PubMed:View item in PubMed

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