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They are not too excited: the possible role of adult-born neurons in epilepsy

Official URL:https://doi.org/10.1016/j.neuron.2006.12.004
PubMed:View item in PubMed
Creators Name:Kempermann, G.
Journal Title:Neuron
Journal Abbreviation:Neuron
Volume:52
Number:6
Page Range:935-937
Date:21 December 2006
Keywords:Epilepsy, Hippocampus, Neurological Models, Neuronal Plasticity, Neurons, Animals
Abstract:In a new study in this issue of Neuron, Jakubs and colleagues report that adult-generated hippocampal granule cells develop particular functional properties when their birth is induced by epileptic seizures. The new neurons showed reduced excitatory synaptic input and decreased excitability. Their functional integration was thus adjusted to the prevailing functional state in the network. By this means, adult neurogenesis might contribute to network homeostasis in the epileptic temporal lobe.
ISSN:0896-6273
Publisher:Cell Press (U.S.A.)
Item Type:Editorial

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