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UniHI: an entry gate to the human protein interactome

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Item Type:Article
Title:UniHI: an entry gate to the human protein interactome
Creators Name:Chaurasia, G. and Iqbal, Y. and Haenig, C. and Herzel, H. and Wanker, E.E. and Futschik, M.E.
Abstract:Systematic mapping of protein–protein interactions has become a central task of functional genomics. To map the human interactome, several strategies have recently been pursued. The generated interaction datasets are valuable resources for scientists in biology and medicine. However, comparison reveals limited overlap between different interaction networks. This divergence obstructs usability, as researchers have to interrogate numerous heterogeneous datasets to identify potential interaction partners for proteins of interest. To facilitate direct access through a single entry gate, we have started to integrate currently available human protein interaction data in an easily accessible online database. It is called UniHI (Unified Human Interactome) and is available at http://www.mdc-berlin.de/unihi. At present, it is based on 10 major interaction maps derived by computational and experimental methods. It includes more than 150 000 distinct interactions between more than 17 000 unique human proteins. UniHI provides researchers with a flexible integrated tool for finding and using comprehensive information about the human interactome.
Keywords:Computer Graphics, Internet, Protein Databases, Protein Interaction Mapping, Systems Integration, User-Computer Interface
Source:Nucleic Acids Research
ISSN:0305-1048
Publisher:Oxford University Press (U.K.)
Volume:35
Number:Database Issue
Page Range:D590-D594
Date:January 2007
Official Publication:https://doi.org/10.1093/nar/gkl817
PubMed:View item in PubMed

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