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Resection of soft tissue sarcoma of the lower limb after evaluation of vascular invasion with intraoperative intravascular ultrasonography

Item Type:Article
Title:Resection of soft tissue sarcoma of the lower limb after evaluation of vascular invasion with intraoperative intravascular ultrasonography
Creators Name:Huenerbein, M. and Hohenberger, P. and Stroszczynski, C. and Bartelt, N. and Schlag, P.M. and Tunn, P.U.
Abstract:Background: This study investigated the value of intravascular ultrasonography (IVUS) in the intraoperative assessment of vascular invasion of soft tissue sarcoma. Methods: In a 4-year interval, of 337 patients with soft tissue sarcoma, 20 patients with tumours of the lower limb in close relation to the neurovascular bundle underwent intraoperative IVUS (20 MHz). Intraoperative findings were correlated with preoperative imaging, histopathological appearance of the resection specimen and patient outcome. Results: Intraoperative IVUS was technically successful in all 20 patients. It correctly predicted vascular involvement (true positive) in ten of 11 patients who required resection of major vessels. There was one false-negative and one false-positive result. With magnetic resonance imaging, there were ten true-positive and three false-positive scans, and one false-negative diagnosis. IVUS improved the assessment of vascular involvement in four of the 20 patients. Histopathological examination confirmed complete resection (R0) in 18 patients. Mean survival was 37 months, and no local recurrence was observed in these patients. Conclusion: Vascular infiltration by soft tissue sarcoma can be visualized accurately by IVUS. This may improve intraoperative decisions about vessel resection.
Keywords:Blood Vessels, Follow-Up Studies, Interventional Ultrasonography, Leg, Limb Salvage, Magnetic Resonance Imaging, Neoplasm Invasiveness, Sarcoma, Soft Tissue Neoplasms, Treatment Outcome
Source:British Journal of Surgery
ISSN:0007-1323
Publisher:John Wiley & Sons (U.K.)
Volume:94
Page Range:168-173
Date:February 2007
Official Publication:https://doi.org/10.1002/bjs.5541
PubMed:View item in PubMed

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