Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity

Item Type:	Article
Title:	Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
Creators Name:	Blueher, M. and Engeli, S. and Kloeting, N. and Berndt, J. and Fasshauer, M. and Batkai, S. and Pacher, P. and Schoen, M.R. and Jordan, J. and Stumvoll, M.
Abstract:	The endocannabinoid system has been suspected to contribute to the association of visceral fat accumulation with metabolic diseases. We determined whether circulating endocannabinoids are related to visceral adipose tissue mass in lean, subcutaneous obese, and visceral obese subjects (10 men and 10 women in each group). We further measured expression of the cannabinoid type 1 (CB(1)) receptor and fatty acid amide hydrolase (FAAH) genes in paired samples of subcutaneous and visceral adipose tissue in all 60 subjects. Circulating 2-arachidonoyl glycerol (2-AG) was significantly correlated with body fat (r = 0.45, P = 0.03), visceral fat mass (r = 0.44, P = 0.003), and fasting plasma insulin concentrations (r = 0.41, P = 0.001) but negatively correlated to glucose infusion rate during clamp (r = 0.39, P = 0.009). In visceral adipose tissue, CB(1) mRNA expression was negatively correlated with visceral fat mass (r = 0.32, P = 0.01), fasting insulin (r = 0.48, P < 0.001), and circulating 2-AG (r = 0.5, P < 0.001), whereas FAAH gene expression was negatively correlated with visceral fat mass (r = 0.39, P = 0.01) and circulating 2-AG (r = 0.77, P < 0.001). Our findings suggest that abdominal fat accumulation is a critical correlate of the dysregulation of the peripheral endocannabinoid system in human obesity. Thus, the endocannabinoid system may represent a primary target for the treatment of abdominal obesity and associated metabolic changes.
Keywords:	2-Arachidonoyl Glycerol 2-AG, Oral Glucose Tolerance Test OGTT, Sterol Regulatory Element–Binding Protein 1c SREBP-1c
Source:	Diabetes
ISSN:	0012-1797
Publisher:	American Diabetes Association
Volume:	55
Number:	11
Page Range:	3053-3060
Date:	1 November 2006
Official Publication:	https://doi.org/10.2337/db06-0812
PubMed:	View item in PubMed

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