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Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus

Item Type:Article
Title:Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus
Creators Name:Pattamadilok, S. and Lee, B.H. and Kumperasart, S. and Yoshimatsu, K. and Okumura, M. and Nakamura, I. and Araki, K. and Khoprasert, Y. and Dangsupa, P. and Panlar, P. and Jandrig, B. and Krueger, D.H. and Klempa, B. and Jaekel, T. and Schmidt, J. and Ulrich, R. and Kariwa, H. and Arikawa, J.
Abstract:Phylogenetic investigations, sequence comparisons, and antigenic cross-reactivity studies confirmed the classification of Thailand virus (THAIV) as a distinct hantavirus species. The examination of sera from 402 rodents trapped in 19 provinces of Thailand revealed that five greater bandicoot rats (Bandicota indica) and one lesser bandicoot rat (B. savilei) from four provinces were focus reduction neutralization test (FRNT) antibody-positive for THAIV. One of 260 patients from Surin province in Thailand (initially suspected of having contracted leptospirosis, but found to be negative) showed symptoms compatible with hemorrhagic fever with renal syndrome (HFRS). The serum of this patient showed high titers of hantavirus-reactive IgM and IgG. FRNT investigations confirmed virus-neutralizing antibodies against THAIV. These observations suggest that THAIV or THAI-like viruses occur throughout Indochina and may represent an additional causative agent of HFRS.
Keywords:Viral Antibodies, Viral Antigens, Fluorescent Antibody Technique, Hantavirus, Hantavirus Infections, Thailand, Animals, Rodentia
Source:American Journal of Tropical Medicine and Hygiene
Publisher:American Society of Tropical Medicine and Hygiene
Page Range:994-1002
Date:November 2006
Official Publication:http://www.ajtmh.org/cgi/content/abstract/75/5/994
PubMed:View item in PubMed

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