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Coping with stress: cellular relaxation techniques

Official URL:https://doi.org/10.1016/j.tcb.2006.10.006
PubMed:View item in PubMed
Creators Name:Hirsch, C. and Gauss, R. and Sommer, T.
Journal Title:Trends in Cell Biology
Journal Abbreviation:Trends Cell Biol
Volume:16
Number:12
Page Range:657-663
Date:December 2006
Keywords:Cytosol, Endoplasmic Reticulum, Endoribonucleases, Heat-Shock Proteins, Heat-Shock Response, Membrane Proteins, Oxidative Stress, Proteasome Endopeptidase Complex, Protein Folding, Protein-Serine-Threonine Kinases, Proteins, Signal Transduction, Ubiquitin-Protein Ligases, Animals
Abstract:Proteins damaged by stressors such as heat, oxidizing conditions or toxic agents are deleterious to cells and must be properly taken care of. Accordingly, misfolded proteins trigger a cellular stress response that aims to either repair defective polypeptides or eliminate faulty elements when salvage is not possible. This stress response provides time for additional stressor-specific pathways that adapt the cell to the changed environment if necessary. Recent studies have investigated how proteins that frustrate the folding machinery are recognized and cleared from the cell. Surprisingly, these clearance mechanisms are not restricted to the protein level. The stress response can also eliminate the mRNA of polypeptides that are refractory to folding.
ISSN:0962-8924
Publisher:Elsevier (The Netherlands)
Item Type:Review

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