Cellular senescence and cancer treatment

Item Type:	Review
Title:	Cellular senescence and cancer treatment
Creators Name:	Schmitt, C.A.
Abstract:	Cellular senescence, an irreversible cell-cycle arrest, reflects a safeguard program that limits the proliferative capacity of the cell exposed to endogenous or exogenous stress signals. A number of recent studies have clarified that an acutely inducible form of cellular senescence may act in response to oncogenic activation as a natural barrier to interrupt tumorigenesis at a premalignant level. Paralleling the increasing insights into premature senescence as a tumor suppressor mechanism, a growing line of evidence identifies cellular senescence as a critical effector program in response to DNA damaging chemotherapeutic agents. This review discusses molecular pathways to stress-induced senescence, the interference of a terminal arrest condition with clinical outcome, and the critical overlap between premature senescence and apoptosis as both tumor suppressive and drug-responsive cellular programs.
Keywords:	Anticancer Therapy, Apoptosis, Cellular Senescence, DNA Damage, Mouse Model, Oncogene, Animals
Source:	Biochimica et Biophysica Acta - Reviews on Cancer
ISSN:	0006-3002
Publisher:	Elsevier
Volume:	1775
Number:	1
Page Range:	5-20
Date:	January 2007
Official Publication:	https://doi.org/10.1016/j.bbcan.2006.08.005
PubMed:	View item in PubMed

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