Helmholtz Gemeinschaft


Cellular senescence and cancer treatment

Item Type:Review
Title:Cellular senescence and cancer treatment
Creators Name:Schmitt, C.A.
Abstract:Cellular senescence, an irreversible cell-cycle arrest, reflects a safeguard program that limits the proliferative capacity of the cell exposed to endogenous or exogenous stress signals. A number of recent studies have clarified that an acutely inducible form of cellular senescence may act in response to oncogenic activation as a natural barrier to interrupt tumorigenesis at a premalignant level. Paralleling the increasing insights into premature senescence as a tumor suppressor mechanism, a growing line of evidence identifies cellular senescence as a critical effector program in response to DNA damaging chemotherapeutic agents. This review discusses molecular pathways to stress-induced senescence, the interference of a terminal arrest condition with clinical outcome, and the critical overlap between premature senescence and apoptosis as both tumor suppressive and drug-responsive cellular programs.
Keywords:Anticancer Therapy, Apoptosis, Cellular Senescence, DNA Damage, Mouse Model, Oncogene, Animals
Source:Biochimica et Biophysica Acta - Reviews on Cancer
Page Range:5-20
Date:January 2007
Official Publication:https://doi.org/10.1016/j.bbcan.2006.08.005
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library