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Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins

Item Type:Review
Title:Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins
Creators Name:Schueler, H. and Matuschewski, K.
Abstract:Efficient and rapid host cell invasion is a prerequisite for an intracellular parasitic life style. Pathogens typically induce receptor-mediated endocytosis and hijack the force-transducing system of a host cell to gain access to a replication-competent niche. In striking contrast, apicomplexan parasites such as Plasmodium, the causative agent of malaria, and the human and animal pathogens Toxoplasma and Cryptosporidium employ their own actomyosin motor machinery to propel themselves into prospective host cells. Understanding the regulation and dynamics of actin-based motility of these parasites is therefore central to understanding their pathogenesis. The parasite genomes harbour surprisingly few potential actin-regulatory proteins indicating that a basic repertoire meets the requirements to regulate actin dynamics. In this article, we summarize our current knowledge of Plasmodium microfilament dynamics and describe its potential players.
Keywords:Actin Polymerization, Actomyosin Motor, Apicomplexa, Gliding Motility, Host Cell Invasion, Malaria, Microfilaments, Plasmodium, Animals
Publisher:Blackwell Synergy
Page Range:1433-1439
Date:November 2006
Official Publication:https://doi.org/10.1111/j.1600-0854.2006.00484.x
PubMed:View item in PubMed

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