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Lipoprotein receptors in Alzheimer's disease

Item Type:Review
Title:Lipoprotein receptors in Alzheimer's disease
Creators Name:Andersen, O.M. and Willnow, T.E.
Abstract:Lipoprotein receptors have important roles in pathological processes that lead to Alzheimer's disease (AD). Previously, they were believed to act mainly by modulating the neuronal metabolism of cholesterol and apolipoprotein E, major risk factors for spontaneous AD. However, recent findings point towards an unexpected new function for lipoprotein receptors in regulation of intracellular transport and processing of the amyloid precursor protein (APP) to give amyloid-beta peptide, the principal component of senile plaques. Here, we will discuss how lipoprotein receptors might modulate distinct steps in neuronal trafficking of APP, and how an intricate balance between opposing receptor activities might be a crucial determinant of APP processing, and of onset and progression of neurodegeneration.
Keywords:Alzheimer Disease, Lipoprotein Receptors, Senile Plaques, Animals
Source:Trends in Neurosciences
ISSN:0166-2236
Publisher:Elsevier (The Netherlands)
Volume:29
Number:12
Page Range:687-694
Date:December 2006
Official Publication:https://doi.org/10.1016/j.tins.2006.09.002
PubMed:View item in PubMed

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