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The rototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo

Official URL:https://doi.org/10.1016/j.neuron.2006.07.025
PubMed:View item in PubMed
Creators Name:Miwa, J.M. and Stevens, T.R. and King, S.L. and Caldarone, B.J. and Ibanez-Tallon, I. and Xiao, C. and Fitzsimonds, R.M. and Pavlides, C. and Lester, H.A. and Picciotto, M.R. and Heintz, N.
Journal Title:Neuron
Journal Abbreviation:Neuron
Page Range:587-600
Date:7 September 2006
Keywords:MOLNEURO, SYSNEURO, Animals, Mice
Abstract:Nicotinic acetylcholine receptors (nAChRs) affect a wide array of biological processes, including learning and memory, attention, and addiction. lynx1, the founding member of a family of mammalian prototoxins, modulates nAChR function in vitro by altering agonist sensitivity and desensitization kinetics. Here we demonstrate, through the generation of lynx1 null mutant mice, that lynx1 modulates nAChR signaling in vivo. Its loss decreases the EC(50) for nicotine by approximately 10-fold, decreases receptor desensitization, elevates intracellular calcium levels in response to nicotine, and enhances synaptic efficacy. lynx1 null mutant mice exhibit enhanced performance in specific tests of learning and memory. Consistent with reports that mutations resulting in hyperactivation of nAChRs can lead to neurodegeneration, aging lynx1 null mutant mice exhibit a vacuolating degeneration that is exacerbated by nicotine and ameliorated by null mutations in nAChRs. We conclude that lynx1 functions as an allosteric modulator of nAChR function in vivo, balancing neuronal activity and survival in the CNS.
Publisher:Cell Press (U.S.A.)
Item Type:Article

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