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A1 adenosine receptors in microglia control glioblastoma-host interaction

Item Type:Article
Title:A1 adenosine receptors in microglia control glioblastoma-host interaction
Creators Name:Synowitz, M. and Glass, R. and Faerber, K. and Markovic, D. and Kronenberg, G. and Herrmann, K. and Schnermann, J. and Nolte, C. and van Rooijen, N. and Kiwit, J. and Kettenmann, H.
Abstract:We report that experimental glioblastoma grow more vigorously in A(1) adenosine receptor (A(1)AR)-deficient mice associated with a strong accumulation of microglial cells at and around the tumors. A(1)ARs were prominently expressed in microglia associated with tumor cells as revealed with immunocytochemistry but low in microglia in the unaffected brain tissue. The A(1)AR could also be detected on microglia from human glioblastoma resections. To study functional interactions between tumor and host cells, we studied glioblastoma growth in organotypical brain slice cultures. A(1)AR agonists suppressed tumor growth. When, however, microglial cells were depleted from the slices, the agonists even stimulated tumor growth. Thus, adenosine attenuates glioblastoma growth acting via A(1)AR in microglia.
Keywords:Adenosine, Brain Neoplasms, Cell Communication, Cell Division, Cultured Cells, Reporter Genes, Genotype, Glioblastoma, Inbred C57BL Mice, Knockout Mice, Transgenic Mice, Microglia, Adenosine A1 Receptor, Animals, Mice
Source:Cancer Research
Publisher:American Association for Cancer Research
Page Range:8550-8557
Date:1 September 2006
Official Publication:https://doi.org/10.1158/0008-5472.CAN-06-0365
PubMed:View item in PubMed

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