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Pillars article: allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 1991. 351: 290-296

Item Type:Article
Title:Pillars article: allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 1991. 351: 290-296
Creators Name:Falk, K. and Roetzschke, O. and Stevanovic, S. and Jung, G. and Rammensee, H.G.
Abstract:The crystal structures of major histocompatibility complex (MHC) moleeules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information about the contents cf MHC grooves is now provided. Moreover, each MHC class I allele has its individual rules to which peptides presented in the groove adhere.
Keywords:Alleles, Amino Acid Motifs, Autoantigens, Epitopes, Histocompatibility Antigens Class I, 20th Century History, Protein Sequence Analysis, Animals
Source:Journal of Immunology
ISSN:0022-1767
Publisher:American Association of Immunologists (U.S.A.)
Volume:177
Number:5
Page Range:2741-2747
Date:1 September 2006
Official Publication:http://www.jimmunol.org/cgi/reprint/177/5/2741
PubMed:View item in PubMed

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