Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia molecule

Item Type:	Article
Title:	Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia molecule
Creators Name:	Luft, F.C.
Abstract:	Pre-eclampsia is a devastating disease of late (after week 20) pregnancy. The condition features hypertension, proteinuria, premature labor, haemolysis, liver abnormalities, thrombocytopenia (HELLP syndrome), seizures (eclampsia) and death [1]. Both mothers and children, if they survive delivery, can expect subsequent increased cardiovascular risk in the future. Pre-eclampsia affects about 5% of the pregnancies in affluent societies; in the rest of the world, the incidence is higher. Suffice it to say, pre-eclampsia is a major world health problem. The group led by Anand Karumanchi et al. [2] has made major contributions in terms of our understanding pre-eclampsia. They showed that pre-eclampsia is associated with a circulating aberrant splice variant of the vascular endothelial growth factor (VEGF) receptor fms-like tyrosine kinase (Flt). This receptor is also an important... [First 10% of the full text]
Keywords:	Pre-eclampsia, Soluble endoglin
Source:	Nephrology Dialysis Transplantation
ISSN:	0931-0509
Publisher:	Oxford University Press
Volume:	21
Number:	11
Page Range:	3052-3054
Date:	November 2006
Official Publication:	https://doi.org/10.1093/ndt/gfl439
PubMed:	View item in PubMed

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