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Crescentic glomerulonephritis and malignancy - guilty or guilt by association?

Item Type:Article
Title:Crescentic glomerulonephritis and malignancy - guilty or guilt by association?
Creators Name:von Vietinghoff, S. and Schneider, W. and Luft, F.C. and Kettritz, R.
Abstract:INTRODUCTION: Rapidly progressive glomerulonephritis (GN) is one of the harrowing challenges in nephrology. The condition is histologically characterized by extracapillary proliferation with crescent formation. Most crescentic glomerulonephritides occur in systemic autoimmune diseases and require prompt immunosuppressive treatment. Occasionally, patients with crescentic GN may be diagnosed with an additional life-threatening disease, namely malignant neoplasms. Immunosuppressive drugs may promote such malignancies. However, some patients are initially diagnosed with both diseases, suggesting a more intimate relationship between crescentic glomerulonephritis and malignancies. We recently encountered a 68-year-old man, referred to us from the urology department because of an increasing serum creatinine. He had initially presented with intermittent haematuria a month earlier. Cystoscopy revealed an exophytic bladder tumour that was resected. Histological examination... [First 10% of the full text]
Keywords:ANCA, Crescentic glomerulonephritis, Malignancy
Source:Nephrology Dialysis Transplantation
Publisher:Oxford University Press
Page Range:3324-3326
Date:November 2006
Official Publication:https://doi.org/10.1093/ndt/gfl456
PubMed:View item in PubMed

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