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Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma

Official URL:https://doi.org/10.1182/blood-2005-09-3843
PubMed:View item in PubMed
Creators Name:Martin-Subero, J.I. and Wlodarska, I. and Bastard, C. and Picquenot, J.M. and Hoeppner, J. and Giefing, M. and Klapper, W. and Siebert, R. and Mathas, S. and Joos, S. and Stein, H. and Doerken, B.
Journal Title:Blood
Journal Abbreviation:Blood
Page Range:401-403
Date:1 July 2006
Keywords:Chromosome Aberrations, Fluorescence In Situ Hybridization, Hodgkin Disease, Peripheral T-Cell Lymphoma, Proto-Oncogene Proteins, Recurrence, Transcription Factors
Abstract:In a recent issue of Blood, Mathas et al suggested elevated BCL3 expression to be functionally important in classical Hodgkin lymphoma (cHL) and peripheral T-cell lymphoma (PTCL). The authors reported strong BCL3 protein expression in the vast majority of cHLs and a subset of PTCLs.1 These results corroborated similar immunohistochemical findings by Canoz et al. Mathas et al reported chromosomal gains of the BCL3 locus in chromosome band 19q13 as a potential cause of BCL3 upregulation in 3 of 6 cHL cell lines and 8 of 37 PTCLs. Here, we provide evidence that not only chromosomal gains but also translocations affecting the BCL3 locus are recurrent in cHL and PTCL. [beginning of text]
Publisher:American Society of Hematology (U.S.A.)
Item Type:Letter

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