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Purinergic signaling and microglia

Item Type:Review
Title:Purinergic signaling and microglia
Creators Name:Faerber, K. and Kettenmann, H.
Abstract:Microglial cells are considered as the pathologic sensors of the brain. In this paper, we review mechanisms of purinergic signaling in microglia. As ATP is not only considered as a physiological signaling substance but is also elevated in pathology, it is not surprising that microglia express a variety of P2X, P2Y and adenosin receptors. As a rapid physiological event, ATP triggers a cationic conductance, increases the potassium conductance and also elicits a calcium response. As a long-term effect, purinergic receptor activation is linked to the movement of microglial processes and, in the context of pathology, to chemotaxis. The purinoreceptors also modulate the release of substances from microglia, such as cytokines, nitric oxide, or superoxide, which are important in the context of a pathologic response.
Keywords:Microglia, Purinergic Receptors, Calcium, Current, Cytokine, Chemokine, Signal Pathway, Animals
Source:Pfluegers Archiv European Journal of Physiology
ISSN:0031-6768
Publisher:Springer (Germany)
Volume:452
Number:5
Page Range:615-621
Date:August 2006
Official Publication:https://doi.org/10.1007/s00424-006-0064-7
PubMed:View item in PubMed

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