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Concordant association of lipid gene variation with a combined HDL/LDL-cholesterol phenotype in two European populations

Item Type:Article
Title:Concordant association of lipid gene variation with a combined HDL/LDL-cholesterol phenotype in two European populations
Creators Name:Bauerfeind, A. and Knoblauch, H. and Costanza, M.C. and Luganskaja, T. and Toliat, M.R. and Nuernberg, P. and Luft, F.C. and Reich, J.G. and Morabia, A.
Abstract:OBJECTIVE: SNP/phenotype associations are difficult to validate. This comparative study demonstrates significant contribution of candidate genes to the variation of a complex cholesterol phenotype, measured in two general populations by a gene-based approach. METHODS: Independent samples of normolipidemic subjects from two Caucasian populations (371 Swiss and 157 Germans) were selected for a case-control-study (high LDL/low HDL versus low LDL/high HDL) with SNP genotypes as independent factors. We examined locus-specific common SNPs that densely cover the genomic regions of 10 lipid genes. RESULTS: Genotype effects were concordant in both ethnic samples, showing that APOE, ABCA1, CETP, and to a lesser degree LDLR, LIPC, and PLTP explained a substantial part of the genetic variation, whereas LPL was associated in only one sample. APOA1, LCAT, and SRB1 exerted no measurable influence. CONCLUSION: This comparison showed that sets of common SNPs representing candidate regions reproducibly validate significant linkage disequilibrium association with a complex metabolic trait. Copyright (c) 2006 S. Karger AG, Basel.
Keywords:Genotype-Phenotype Association, Complex Polygenic Trait, HDL-Cholesterol, LDL-Cholesterol, Lipids, Single Nucleotide Polymorphisms
Source:Human Heredity
ISSN:0001-5652
Publisher:Karger (Switzerland)
Volume:61
Number:3
Page Range:123-131
Date:August 2006
Official Publication:https://doi.org/10.1159/000093773
PubMed:View item in PubMed

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