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Probucol inhibits in-stent thrombosis and neointimal hyperplasia by promoting re-endothelialization

Item Type:Article
Title:Probucol inhibits in-stent thrombosis and neointimal hyperplasia by promoting re-endothelialization
Creators Name:Tanous, D. and Braesen, J.H. and Choy, K. and Wu, B.J. and Kathir, K. and Lau, A. and Celermajer, D.S. and Stocker, R.
Abstract:BACKGROUND: Evidence suggests that delayed re-endothelialization is responsible for in-stent thrombosis. Probucol inhibits neointimal thickening in animals via enhanced re-endothelialization and is the only oral drug that consistently inhibits restenosis after coronary angioplasty in humans. Here, we examined the effects of probucol on re-endothelialization and neointimal formation in a stent model. METHODS AND RESULTS: New Zealand White rabbits were fed a hypercholesterolemic diet with probucol (1%) or without (control) (n=11 each) for 6 weeks. At 2 weeks, endothelial denudation and stenting of the iliac artery was performed. Iliac arteries were harvested at week 6, and stented segments sectioned and analyzed. Compared with control, probucol increased in-stent re-endothelialization (74+/-6% in controls versus 93+/-3% in probucol-treated; P=0.008), and decreased average luminal stenosis (58+/-27 versus 31+/-16%; P=0.01) and stent depth (619+/-310 versus 314+/-158mum; P=0.009). Compared with control, probucol also decreased accumulation of macrophages in the neointima. Furthermore, none of the probucol-treated rabbits had in-stent thrombosis, whereas four of eleven control rabbits showed thrombosis (P=0.04). CONCLUSIONS: Probucol demonstrates anti-restenotic and appears to have anti-thrombotic properties that are likely related to its ability to promote in-stent re-endothelialization.
Keywords:Stents, Restenosis, Endothelium, Antioxidants, Thrombosis, Animals, Rabbits
Source:Atherosclerosis
ISSN:0021-9150
Publisher:Elsevier (The Netherlands)
Volume:189
Number:2
Page Range:342-349
Date:December 2006
Official Publication:https://doi.org/10.1016/j.atherosclerosis.2006.01.025
PubMed:View item in PubMed

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