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Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats

Item Type:Article
Title:Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats
Creators Name:Galvez, B. and de Castro, J. and Herold, D. and Dubrovska, G. and Arribas, S. and Gonzalez, M.C. and Aranguez, I. and Luft, F.C. and Ramos, M.P. and Gollasch, M. and Fernandez Alfonso, M.S.
Abstract:Objective— Perivascular adipose tissue of normotensive rats releases a transferable factor that induces relaxation by opening voltage-dependent K+ (Kv) channels. The relevance of these observations to hypertension is unknown.Methods and Results— We characterized mesenteric perivascular adipose tissue from 3-month-old Wistar Kyoto rats (WKY) and aged-matched spontaneously hypertensive rats (SHR). Mesenteric bed (MB) weight and MB total lipid content were lower in SHR than in WKY. Freshly isolated MB adipocytes were smaller in SHR. Plasma triglycerides, glycerol, nonesterified free-fatty acids, and cholesterol were also lower in SHR. Plasma and mesenteric leptin were correlated with the quantity of mesenteric fat. To study vascular function, the MB was cannulated and perfused at a constant 2 mL/min flow. The Kv channel blocker 4-aminopyridine (4-AP; 2 mmol/L) increased perfusion pressure less in SHR MB than WKY and was directly correlated with the mesenteric fat amount. In isolated mesenteric artery rings, 4-AP (2 mmol/L) induced a contractile effect that was attenuated in SHR compared with WKY. The anticontractile effects of perivascular fat were reduced in SHR mesenteric artery rings compared with WKY.Conclusions— Differences in visceral perivascular adipose tissue mass and function may contribute to the increased vascular resistance observed in SHR.
Keywords:Perivascular adipose tissue, ADRF, Mesenteric arteries, SHR
Source:Arteriosclerosis Thrombosis and Vascular Biology
ISSN:1079-5642
Publisher:American Heart Association (U.S.A.)
Volume:26
Page Range:1297-1302
Date:June 2006
Official Publication:https://doi.org/10.1161/01.ATV.0000220381.40739.dd
PubMed:View item in PubMed

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