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Oncogene-induced senescence: putting the brakes on tumor development

Item Type:Review
Title:Oncogene-induced senescence: putting the brakes on tumor development
Creators Name:Braig, M. and Schmitt, C.A.
Abstract:Cellular senescence, a permanent cell cycle arrest, is considered a safeguard mechanism that may prevent aged or abnormal cells from further expansion. Although the term ‘‘replicative senescence’’ stands for the widely accepted model of a terminal growth arrest due to telomere attrition, the significance of ‘‘oncogene-inducible senescence’’ remained an issue of debate over the years. A number of recent studies now show the effect of this acute and telomere-independent form of senescence as a tumor-protective, fail-safe mechanism in vivo that shares conceptual and possibly therapeutic similarities with the genetically encoded apoptosis machinery. (Cancer Res 2006; 66(6): 2881-4)
Keywords:Cell Aging, Neoplastic Cell Transformation, Oncogenes, Precancerous Conditions, Animals
Source:Cancer Research
ISSN:0008-5472
Publisher:American Association for Cancer Research (U.S.A.)
Volume:66
Number:6
Page Range:2881-2884
Date:15 March 2006
Official Publication:https://doi.org/10.1158/0008-5472.CAN-05-4006
PubMed:View item in PubMed

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