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Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring

Item Type:Article
Title:Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring
Creators Name:Bick-Sander, A. and Steiner, B. and Wolf, S.A. and Babu, H. and Kempermann, G.
Abstract:Voluntary wheel running of mice in pregnancy and lactation led to a twofold increase in hippocampal precursor-cell proliferation and in the number of Prox1-expressing lineage-determined cells at postnatal day 8 (P8). At P36, the number of newly generated granule cells approximately doubled, resulting in a 40% higher total number of granule cells in pups from running dams as compared with controls. Cell proliferation at embryonic day 15 (E15), in contrast, was decreased in the progeny of exercising mice, and the birth weight was reduced. At P49, body weight had normalized, and hippocampal neurogenesis was not different between the two groups. mRNA for FGF2 was expressed at higher levels at E15 and P8 in runner pups, whereas VEGF was increased only at E15. Insulin-like growth factor did not show differences at any time point. At P36, no differences for any of the factors were found. Our data indicate that maternal behavior and physical activity affects infantile growth-factor expression and can transiently stimulate postnatal hippocampal development in the offspring.
Keywords:Exercise, Hippocampus, Animals, Mice
Source:Proceedings of the National Academy of Sciences of the United States of America
ISSN:0027-8424
Publisher:National Academy of Sciences (U.S.A.)
Volume:103
Number:10
Page Range:3852-3857
Date:7 March 2006
Official Publication:https://doi.org/10.1073/pnas.0502644103
PubMed:View item in PubMed

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