Helmholtz Gemeinschaft


Toward automatic reconstruction of a highly resolved tree of life

Item Type:Article
Title:Toward automatic reconstruction of a highly resolved tree of life
Creators Name:Ciccarelli, F.D. and Doerks, T. and von Mehring, C. and Creevey, C.J. and Snel, B. and Bork, P.
Abstract:We have developed an automatable procedure for reconstructing the tree of life with branch lengths comparable across all three domains. The tree has its basis in a concatenation of 31 orthologs occurring in 191 species with sequenced genomes. It revealed interdomain discrepancies in taxonomic classification. Systematic detection and subsequent exclusion of products of horizontal gene transfer increased phylogenetic resolution, allowing us to confirm accepted relationships and resolve disputed and preliminary classifications. For example, we place the phylum Acidobacteria as a sister group of delta-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor.
Keywords:Amino Acyl-tRNA Synthetases, Archaea, Bacteria, Computational Biology, Eukaryotic Cells, Evolution, Horizontal Gene Transfer, Genome, Invertebrates, Phylogeny, Plants, Protein Biosynthesis, Ribosomal Proteins, Vertebrates, Animals
Publisher:American Association for the Advancement of Science
Page Range:1283-1287
Date:3 March 2006
Official Publication:https://doi.org/10.1126/science.1123061
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library