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Molecular genetics of human hypertension

Item Type:Review
Title:Molecular genetics of human hypertension
Creators Name:Gong, M. and Huebner, N.
Abstract:EH (essential hypertension) is a major public health problem in many countries due to its high prevalence and its association with coronary heart disease, stroke, renal disease, peripheral vascular disease and other disorders. Epidemiological studies have demonstrated that EH is heritable. Owing to the fact that blood pressure is controlled by cardiac output and total peripheral resistance, many molecular pathways are believed to be involved in the disease. In this review, recent genetic studies investigating the molecular basis of EH, including different molecular pathways, will be highlighted.
Keywords:Blood Pressure, Candidate Gene, Genetics, Hypertension, Molecular Pathway, Renin-Angiotensin-Aldosterone System (RAAS).
Source:Clinical Science
ISSN:0143-5221
Publisher:Portland Press (U.K.)
Volume:110
Number:3
Page Range:315-326
Date:March 2006
Official Publication:https://doi.org/10.1042/CS20050208
PubMed:View item in PubMed

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