Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia

Item Type:	Review
Title:	Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia
Creators Name:	Dechend, R. and Homuth, V. and Wallukat, G. and Mueller, D.N. and Krause, M. and Dudenhausen, J. and Haller, H. and Luft, F.C.
Abstract:	Immune mechanisms and circulating mediators may be important in the pathogenesis of preeclampsia. We review our findings on agonistic antibodies against the angiotensin II (Ang II) receptor (AT1-AA) and their possible role in the pathogenesis of this disorder. AT1-AA appear in the course of preeclampsia and are largely gone by 6 weeks after delivery. AT1-AA detection relies on a bioassay using spontaneously beating neonatal rat cardiomyocytes. Their specificity has been documented by other methods, including Western blotting, co-localization, and co-immunoprecipitation experiments. AT1-AA induce signaling in vascular cells and trophoblasts including transcription factor activation. The signaling results in tissue factor production and reactive oxygen species generation, both of which have been implicated in preeclampsia. The role of AT1-AA in preeclampsia and other severe hypertensive conditions has not yet been proved with certainty. However, we believe the findings are compelling and warrant further study.
Keywords:	Preeclampsia, Angiotensin, Agonistic autoantibodies, Tissue factor, Reactive oxygen species
Source:	Journal of the Society for Gynecologic Investigation
ISSN:	1071-5576
Volume:	13
Page Range:	79-86
Date:	February 2006
Official Publication:	https://doi.org/10.1016/j.jsgi.2005.11.006
PubMed:	View item in PubMed

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