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SMART 5: domains in the context of genomes and networks

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Item Type:Article
Title:SMART 5: domains in the context of genomes and networks
Creators Name:Letunic, I. and Copley, R.R. and Pils, B. and Pinkert, S. and Schultz, J. and Bork, P.
Abstract:The Simple Modular Architecture Research Tool (SMART) is an online resource (http://smart.embl.de/) used for protein domain identification and the analysis of protein domain architectures. Many new features were implemented to make SMART more accessible to scientists from different fields. The new 'Genomic' mode in SMART makes it easy to analyze domain architectures in completely sequenced genomes. Domain annotation has been updated with a detailed taxonomic breakdown and a prediction of the catalytic activity for 50 SMART domains is now available, based on the presence of essential amino acids. Furthermore, intrinsically disordered protein regions can be identified and displayed. The network context is now displayed in the results page for more than 350 000 proteins, enabling easy analyses of domain interactions.
Keywords:Catalysis, Catalytic Domain, Protein Databases, Genomics, Internet, Biological Models, Multiprotein Complexes, Tertiary Protein Structure, Sequence Alignment, Protein Sequence Analysis, User-Computer Interface
Source:Nucleic Acids Research
Publisher:Oxford University Press
Number:Database Issue
Page Range:D257-D260
Date:1 January 2006
Official Publication:https://doi.org/10.1093/nar/gkj079
PubMed:View item in PubMed

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