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Balancing cell adhesion and Wnt signaling, the key role of beta-catenin

Official URL:https://doi.org/10.1016/j.gde.2005.12.007
PubMed:View item in PubMed
Creators Name:Brembeck, F.H. and Rosario, M. and Birchmeier, W.
Journal Title:Current Opinion in Genetics & Development
Journal Abbreviation:Curr Opin Dev
Volume:16
Number:1
Page Range:51-59
Date:February 2006
Keywords:Amino Acid Sequence, Cell Adhesion, Biological Models, Molecular Sequence Data, Neoplasm Proteins, Neoplasms, Phosphorylation, Proto-Oncogenes, Amino Acid Sequence Homology, Signal Transduction, Genetic Transcription, Tyrosine, Wnt Proteins, beta Catenin, Animals
Abstract:Controlled regulation of cell proliferation and differentiation is essential for embryonic development and requires the coordinated regulation of cell-cell adhesion and gene transcription. The armadillo repeat protein beta-catenin is an important integrator of both processes. Beta-catenin acts in the Wnt signaling pathway, activating the transcription of crucial target genes responsible for cellular proliferation and differentiation. Beta-catenin also controls E-cadherin-mediated cell adhesion at the plasma membrane and mediates the interplay of adherens junction molecules with the actin cytoskeleton. Both functions of beta-catenin are de-regulated in human malignancies, thereby leading both to the loss of cell-cell adhesion and to the increased transcription of Wnt target genes.
ISSN:0959-437X
Publisher:Elsevier (The Netherlands)
Additional Information:The original publication is available at www.sciencedirect.com
Item Type:Review

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