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| Item Type: | Review |
|---|---|
| Title: | Balancing cell adhesion and Wnt signaling, the key role of beta-catenin |
| Creators Name: | Brembeck, F.H., Rosario, M. and Birchmeier, W. |
| Abstract: | Controlled regulation of cell proliferation and differentiation is essential for embryonic development and requires the coordinated regulation of cell-cell adhesion and gene transcription. The armadillo repeat protein beta-catenin is an important integrator of both processes. Beta-catenin acts in the Wnt signaling pathway, activating the transcription of crucial target genes responsible for cellular proliferation and differentiation. Beta-catenin also controls E-cadherin-mediated cell adhesion at the plasma membrane and mediates the interplay of adherens junction molecules with the actin cytoskeleton. Both functions of beta-catenin are de-regulated in human malignancies, thereby leading both to the loss of cell-cell adhesion and to the increased transcription of Wnt target genes. |
| Keywords: | Amino Acid Sequence, Cell Adhesion, Biological Models, Molecular Sequence Data, Neoplasm Proteins, Neoplasms, Phosphorylation, Proto-Oncogenes, Amino Acid Sequence Homology, Signal Transduction, Genetic Transcription, Tyrosine, Wnt Proteins, beta Catenin, Animals |
| Source: | Current Opinion in Genetics & Development |
| ISSN: | 0959-437X |
| Publisher: | Elsevier |
| Volume: | 16 |
| Number: | 1 |
| Page Range: | 51-59 |
| Date: | February 2006 |
| Additional Information: | The original publication is available at www.sciencedirect.com |
| Official Publication: | https://doi.org/10.1016/j.gde.2005.12.007 |
| PubMed: | View item in PubMed |
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