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Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24

Official URL:https://doi.org/10.1086/498619
PubMed:View item in PubMed
Creators Name:Schumacher, J. and Kaneva, R. and Jamra, R.A. and Diaz, G.O. and Ohlraun, S. and Milanova, V. and Lee, Y.A. and Rivas, F. and Mayoral, F. and Fuerst, R. and Flaquer, A. and Windemuth, C. and Gay, E. and Sanz, S. and Gonzalez, M.J. and Gil, S. and Cabaleiro, F. and del Rio, F. and Perez, F. and Haro, J. and Kostov, C. and Chorbov, V. and Nikolova-Hill, A. and Stoyanova, V. and Onchev, G. and Kremensky, I. and Strauch, K. and Schulze, T.G. and Nuernberg, P. and Gaebel, W. and Klimke, A. and Auburger, G. and Wienker, T.F. and Kalaydjieva, L. and Propping, P. and Cichon, S. and Jablensky, A. and Rietschel, M. and Noethen, M.M.
Journal Title:American Journal of Human Genetics
Journal Abbreviation:Am J Hum Genet
Volume:77
Number:6
Page Range:1102-1111
Date:1 December 2005
Keywords:Bipolar Disorder, Human Chromosomes, Pair 1, Human Chromosomes, Pair 4, Human Chromosomes, Pair 6, European Continental Ancestry Group, Genetic Markers, Genetic Predisposition to Disease, Human Genome, Gypsies, Lod Score, Physical Chromosome Mapping
Abstract:We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian descent and further fine mapping of the 1p34-p36, 4q28-q31, and 6q15-q24 regions. An additional sample of 56 German families (280 individuals) was included for this fine-mapping step. The highest nonparametric linkage scores obtained in the fine mapping were 5.49 for 4q31 and 4.87 for 6q24 in the Romany families and 3.97 for 1p35-p36 in the Spanish sample. MOD-score (LOD scores maximized over genetic model parameters) analysis provided significant evidence of linkage to 4q31 and at least borderline significance for the 1p and 6q regions. On the basis of these results and previous positive research findings, 4q31 and 6q24 should now be considered confirmed BPAD susceptibility loci, and 1p35-p36 is proposed as a new putative locus that requires confirmation in replication studies.
ISSN:0002-9297
Publisher:University of Chicago Press (U.S.A.)
Item Type:Article

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