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Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus

Item Type:Article
Title:Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
Creators Name:Kronenberg, G. and Bick-Sander, A. and Bunk, E. and Wolf, C. and Ehninger, D. and Kempermann, G.
Abstract:Physical activity induces adult hippocampal neurogenesis. We here show that the acute up-regulating effect of voluntary wheel running on precursor cell proliferation decreases with continued exercise, but that continued exercise reduces the age-dependent decline in adult neurogenesis. Cell proliferation peaked at 3 days of running. After 32 days of exercise this response returned to baseline. Running-induced proliferation of transiently amplifying progenitor cells led to a consecutive increase in the number of more mature cells. Increasing age reduced adult neurogenesis at 9 months to 50% of the value at 6 weeks and to 17% at the age of 2 years. At both 1 and 2 years, precursor cell divisions remained inducible by physical activity. Exercise from 3 to 9 months of age significantly reduced the age-dependent decline in cell proliferation but (presumably in the absence of additional stimuli) did not maintain net neurogenesis at levels corresponding to a younger age. We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells.
Keywords:Adult neurogenesis, Stem cell, Progenitor cell, Wheel running, Hippocampus, Animals, Mice
Source:Neurobiology of Aging
Page Range:1505-1513
Date:October 2006
Official Publication:https://doi.org/10.1016/j.neurobiolaging.2005.09.016
PubMed:View item in PubMed

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