CD52 is not a promising immunotherapy target for most patients with multiple myeloma

Item Type:	Article
Title:	CD52 is not a promising immunotherapy target for most patients with multiple myeloma
Creators Name:	Westermann, J. and Maschmeyer, G. and Lessen, A. and Doerken, B. and Pezzutto, A.
Abstract:	The aim of our study was to evaluate CD52 as a target molecule for antibody therapy for multiple myeloma. Twenty consecutive bone marrow samples from myeloma patients were studied by flow cytometry using antibodies against CD45, CD38, CD138, CD3, CD19, and CD52. Most myeloma cells did not express CD52; CD52 expression was found only in a small subpopulation of plasma cells with a CD45+CD38++ phenotype. In contrast, the major fraction of myeloma cells (CD45–CD38++) was CD52−.Treatment of myeloma patients with anti—CD52 antibodies with the aim to reduce the number of myeloma cells in the CD45+CD38++ subfraction, which possibly contains a proliferative progenitor cell pool, would be at best a highly experimental approach.We conclude that CD52 is not a promising target for antibody—based therapies for most patients with multiple myeloma.
Keywords:	Multiple myeloma, CD52, Alemtuzumab, Flow cytometry
Source:	International Journal of Hematology
ISSN:	0925-5710
Volume:	82
Page Range:	248-250
Date:	1 October 2005
Official Publication:	https://doi.org/10.1532/IJH97.E0435
PubMed:	View item in PubMed

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