Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients

Item Type:	Article
Title:	Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients
Creators Name:	Stein, U. and Wunderlich, V. and Haensch, W. and Schmidt-Peter, P.
Abstract:	The expression of the mdr1 gene was evaluated at the RNA level by northern and slot blot analysis, and at the protein level by immunohistochemistry, in a total of 29 bone and 32 soft tissue sarcomas. All patients, mainly adults, had not received previous chemotherapy. Of the tumours investigated, 69% were mdr1-positive. An intermediate mdr1 expression was observed most frequently, with the exception of osteosarcomas (high) and malignant fibrous histiocytomas (low). Detection of P-glycoprotein in selected tumours revealed consistent results. However, no conclusion can be drawn as yet regarding correlation of mdr1 expression and drug resistance in patients.
Keywords:	Bone Neoplasms, Carrier Proteins, Drug Resistance, Gene Expression, Membrane Glycoproteins, Messenger RNA, Neoplasm Proteins, Neoplasm RNA, Osteosarcoma, P-Glycoprotein, Sarcoma, Soft Tissue Neoplasms
Source:	European Journal of Cancer
ISSN:	0959-8049
Publisher:	Pergamon Press
Volume:	29A
Number:	14
Page Range:	1979-1981
Date:	1993
Official Publication:	https://doi.org/10.1016/0959-8049(93)90457-Q
PubMed:	View item in PubMed

Repository Staff Only: item control page