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Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients

Item Type:Article
Title:Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients
Creators Name:Stein, U. and Wunderlich, V. and Haensch, W. and Schmidt-Peter, P.
Abstract:The expression of the mdr1 gene was evaluated at the RNA level by northern and slot blot analysis, and at the protein level by immunohistochemistry, in a total of 29 bone and 32 soft tissue sarcomas. All patients, mainly adults, had not received previous chemotherapy. Of the tumours investigated, 69% were mdr1-positive. An intermediate mdr1 expression was observed most frequently, with the exception of osteosarcomas (high) and malignant fibrous histiocytomas (low). Detection of P-glycoprotein in selected tumours revealed consistent results. However, no conclusion can be drawn as yet regarding correlation of mdr1 expression and drug resistance in patients.
Keywords:Bone Neoplasms, Carrier Proteins, Drug Resistance, Gene Expression, Membrane Glycoproteins, Messenger RNA, Neoplasm Proteins, Neoplasm RNA, Osteosarcoma, P-Glycoprotein, Sarcoma, Soft Tissue Neoplasms
Source:European Journal of Cancer
Publisher:Pergamon Press
Page Range:1979-1981
Official Publication:https://doi.org/10.1016/0959-8049(93)90457-Q
PubMed:View item in PubMed

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