Grundlagen der molekularen Diagnostik und Therapie maligner Tumoren [Basics of molecular diagnostics and therapy of malignant tumors]

Item Type:	Article
Title:	Grundlagen der molekularen Diagnostik und Therapie maligner Tumoren [Basics of molecular diagnostics and therapy of malignant tumors]
Creators Name:	Daniel, P.T. and Doerken, B.
Abstract:	Recent insights in disease pathogenesis and mechanisms of resistance to therapy of malignant tumors provide a rational basis for the development of novel therapeutic strategies that target genetic defects and deregulated signaling events in malignant tumors. In contrast to conventional therapeutics, small molecule inhibitors or monoclonal antibodies allow for a far more selective, targeted therapy of tumors that carry a corresponding target structure or gene expression profile. Molecular therapeutics therefore necessitate clinical deployment of genetic diagnostics for the identification of those patients who have a chance to benefit from these novel targeted therapies.
Keywords:	Malignant Tumors, Molecular Diagnostics, Molecular Therapy, Oncogene, Pharmacogenetics, Targeted Therapy, Animals
Source:	Internist
ISSN:	0020-9554
Publisher:	Springer
Volume:	46
Number:	8
Page Range:	835-846
Date:	12 July 2005
Official Publication:	https://doi.org/10.1007/s00108-005-1470-1
PubMed:	View item in PubMed

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