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Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients. Sibutramine and blood pressure

Item Type:Article
Title:Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients. Sibutramine and blood pressure
Creators Name:Birkenfeld, A.L. and Schroeder, C. and Pischon, T. and Tank, J. and Luft, F.C. and Sharma, A.M. and Jordan, J.
Abstract:Background Sibutramine, a serotonin and norepinephrine transporter blocker, is a common adjunctive obesity treatment. Acute studies in healthy subjects suggested that an inhibitory central nervous mechanism might attenuate the peripheral stimulatory effect on the sympathetic nervous system. This notion has not been tested in overweight and obese patients. Methods We conducted a randomized, controlled clinical study in hypertensive patients with BMI ≥ 27 to < 40 kg/m2. After 4 week placebo run-in period patients were randomized to four different antihypertensive treatments or placebo. After 4 weeks of antihypertensive therapy, patients were additionally treated with sibutramine 15 mg o. d. for 3 months. Patients underwent cardiovascular autonomic reflex testing and a graded head-up tilt test at the end of each phase. Results Mean body weight decreased from 98.5±4 to 94.7±4 kg (p<0.05) between end of placebo run-in and end of sibutramine treatment. Supine blood pressure was 154±3/80±2, 145±3/76±2 and 150±3/79±2mmHg at the end of placebo run-in, after antihypertensive titration (ns) and end of sibutramine treatment (ns), respectively. Blood pressure was affected similarly during head up tilt testing. The systolic blood pressure response to cold pressor testing was diminished with sibutramine (p<0.01). Sibutramine decreased low frequency systolic blood pressure oscillations in the supine position (p<0.01). Conclusions Resting blood pressure tends to increase with sibutramine, whereas blood pressure during sympathetic stimulation and low frequency blood pressure oscillations are decreased. These paradoxical changes are consistent with previous studies in healthy subjects and suggest a combination of peripheral and central nervous system mechanisms.
Keywords:Norepinephrine transporter, Nympathetic nervous system, Obesity, Hypertension
Source:Clinical Autonomic Research
Page Range:200-206
Date:1 January 2005
Official Publication:https://doi.org/10.1007/s10286-005-0270-y
PubMed:View item in PubMed

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