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YB-1 provokes breast cancer through the induction of chromosomal instability that emerges from mitotic failure and centrosome amplification

Item Type:Article
Title:YB-1 provokes breast cancer through the induction of chromosomal instability that emerges from mitotic failure and centrosome amplification
Creators Name:Bergmann, S. and Royer-Pokora, B. and Fietze, E. and Juerchott, K. and Hildebrandt, B. and Trost, D. and Leenders, F. and Claude, J.C. and Theuring, F. and Bargou, R. and Dietel, M. and Royer, H.D.
Abstract:YB-1 protein levels are elevated in most human breast cancers, and high YB-1 levels have been correlated with drug resistance and poor clinical outcome. YB-1 is a stress-responsive, cell cycle-regulated transcription factor with additional functions in RNA metabolism and translation. In this study, we show in a novel transgenic mouse model that human hemagglutinin-tagged YB-1 provokes remarkably diverse breast carcinomas through the induction of genetic instability that emerges from mitotic failure and centrosome amplification. The increase of centrosome numbers proceeds during breast cancer development and explanted tumor cell cultures show the phenotype of ongoing numerical chromosomal instability. These data illustrate a mechanism that might contribute to human breast cancer development.
Keywords:YB-1, Breast Cancer, Chromosomal Instability, Mouse Model, Animals, Mice
Source:Cancer Research
ISSN:0008-5472
Publisher:American Association for Cancer Research (U.S.A.)
Volume:65
Number:10
Page Range:4078-4087
Date:16 May 2005
Official Publication:https://doi.org/10.1158/0008-5472.CAN-04-4056
PubMed:View item in PubMed

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