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Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection

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Official URL:https://doi.org/10.1084/jem.20041204
PubMed:View item in PubMed
Creators Name:Kursar, M. and Hoepken, U.E. and Koch, M. and Koehler, A. and Lipp, M. and Kaufmann, S.H. and Mittruecker, H.W.
Journal Title:Journal of Experimental Medicine
Journal Abbreviation:J Exp Med
Volume:201
Number:9
Page Range:1447-1457
Date:2 May 2005
Keywords:Antigen-Presenting Cells, Bone Marrow Cells, CD8-Positive T-Lymphocytes, Chemokine CCL19, Chemokine CCL21, DNA Primers, Flow Cytometry, Immunologic Memory, Listeria Infections, Listeria monocytogenes, Lymphocyte Activation, Major Histocompatibility Complex, CCR7 Receptors, Chemokine Receptors, T-Lymphocyte Subsets, Animals, Mice
Abstract:Effective priming of T cell responses depends on cognate interactions between naive T cells and professional antigen-presenting cells (APCs). This contact is the result of highly coordinated migration processes, in which the chemokine receptor CCR7 and its ligands, CCL19 and CCL21, play a central role. We used the murine Listeria monocytogenes infection model to characterize the role of the CCR7/CCR7 ligand system in the generation of T cell responses during bacterial infection. We demonstrate that efficient priming of naive major histocompatibility complex (MHC) class Ia-restricted CD8+ T cells requires CCR7. In contrast, MHC class Ib-restricted CD8+ T cells and MHC class II-restricted CD4+ T cells seem to be less dependent on CCR7; memory T cell responses are independent of CCR7. Infection experiments with bone marrow chimeras or mice reconstituted with purified T cell populations indicate that CCR7 has to be expressed on CD8+ T cells and professional APCs to promote efficient MHC class Ia-restricted T cell priming. Thus, different T cell subtypes and maturation stages have discrete requirements for CCR7.
ISSN:0022-1007
Publisher:Rockefeller University Press (U.S.A.)
Additional Information:Copyright (c) 2005 by The Rockefeller University Press
Item Type:Article

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