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CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations

Item Type:Article
Title:CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations
Creators Name:Arce, S. and Luger, E. and Muehlinghaus, G. and Cassese, G. and Hauser, A. and Horst, A. and Lehnert, K. and Odendahl, M. and Hoenemann, D. and Heller, K.D. and Kleinschmidt, H. and Berek, C. and Doerner, T. and Krenn, V. and Hiepe, F. and Bargou, R. and Radbruch, A. and Manz, R.A.
Abstract:Despite the important role immunoglobulin G (IgG)-secreting plasma cells play in memory immune responses, the differentiation and homeostasis of these cells are not completely understood. Here, we studied the differentiation of human IgG-secreting cells ex vivo and in vitro, identifying these cells by the cellular affinity matrix technology. Several subpopulations of IgG-secreting cells were identified among the cells isolated from tonsils and bone marrow, particularly differing in the expression levels of CD9, CD19, and CD38. CD38 low IgG-secreting cells were present exclusively in the tonsils. A major fraction of these cells appeared to be early plasma cell precursors, as upon activation of B cells in vitro, IgG secretion preceded up-regulation of CD38, and on tonsillar sections, IgG-containing, CD38 low cells with a plasmacytoid phenotype were found in follicles, where plasma cell differentiation starts. A unitary phenotype of migratory peripheral blood IgG-secreting cells suggests that all bone marrow plasma cell populations share a common precursor cell. These data are compatible with a multistep model for plasma cell differentiation and imply that a common CD38 low IgG-secreting precursor gives rise to a diverse plasma cell compartment.
Keywords:Antibodies, B lymphocytes, Cellular differentiation, Memory
Source:Journal of Leukocyte Biology
Page Range:1022-1028
Date:1 January 2004
Official Publication:https://doi.org/10.1189/jlb.0603279
PubMed:View item in PubMed

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