Physiology of microglial cells

Item Type:	Article
Title:	Physiology of microglial cells
Creators Name:	Faerber, K. and Kettenmann, H.
Abstract:	Microglial cells in culture and in situ express a defined pattern of K + channels, which is distinct from that of other glial cells and neurons. This pattern undergoes defined changes with microglial activation. As expected for a cell with immunological properties, microglia express a variety of cytokine and chemokine receptors, which are linked to the mobilization of Ca2+ (cytosolic free calcium) from internal stores. Microglial cells also have the capacity to respond to neuronal activity: they express receptors for the major excitatory receptor glutamate and the main inhibitory receptor GABA (γ-amino butyric acid). By expressing purinergic receptors, microglia can sense astrocyte activity in the form of Ca2+ waves. Activation of transmitter receptors can affect cytokine release which is a potential means as to how brain activity can affect immune function.
Keywords:	Calcium, Ion channels, Microglia, Patch clamp, Receptors, Animals
Source:	Brain Research Reviews
ISSN:	0165-0173
Publisher:	Elsevier
Volume:	48
Number:	2
Page Range:	133-143
Date:	1 January 2005
Official Publication:	https://doi.org/10.1016/j.brainresrev.2004.12.003
PubMed:	View item in PubMed

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