Helmholtz Gemeinschaft


Physiology of microglial cells

Item Type:Article
Title:Physiology of microglial cells
Creators Name:Faerber, K. and Kettenmann, H.
Abstract:Microglial cells in culture and in situ express a defined pattern of K + channels, which is distinct from that of other glial cells and neurons. This pattern undergoes defined changes with microglial activation. As expected for a cell with immunological properties, microglia express a variety of cytokine and chemokine receptors, which are linked to the mobilization of Ca2+ (cytosolic free calcium) from internal stores. Microglial cells also have the capacity to respond to neuronal activity: they express receptors for the major excitatory receptor glutamate and the main inhibitory receptor GABA (γ-amino butyric acid). By expressing purinergic receptors, microglia can sense astrocyte activity in the form of Ca2+ waves. Activation of transmitter receptors can affect cytokine release which is a potential means as to how brain activity can affect immune function.
Keywords:Calcium, Ion channels, Microglia, Patch clamp, Receptors, Animals
Source:Brain Research Reviews
Page Range:133-143
Date:1 January 2005
Official Publication:https://doi.org/10.1016/j.brainresrev.2004.12.003
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library