Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors

Item Type:	Article
Title:	Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors
Creators Name:	von Haehling, S. and Genth-Zotz, S. and Bolger, A.P. and Kalra, P.R. and Kemp, M. and Adcock, I.M. and Poole-Wilson, P.A. and Dietz, R. and Anker, S.D.
Abstract:	Increased levels of tumor necrosis factor-alpha (TNF-alpha) correlate with poor prognoses in chronic heart failure (CHF). This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion. The beta-blocker bisoprolol abolishes this effect.
Keywords:	Adrenergic and beta Receptors, Adrenergic beta-Antagonists, Bisoprolol, Cardiovascular Agents, Heart Failure, Isoproterenol, Lipopolysaccharides, Norepinephrine, Tumor Necrosis Factor-alpha
Source:	American Journal of Cardiology
ISSN:	0002-9149
Volume:	95
Page Range:	885-889
Date:	1 January 2005
Official Publication:	https://doi.org/10.1016/j.amjcard.2004.12.022
PubMed:	View item in PubMed

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