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Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors

Item Type:Article
Title:Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors
Creators Name:von Haehling, S., Genth-Zotz, S., Bolger, A.P., Kalra, P.R., Kemp, M., Adcock, I.M., Poole-Wilson, P.A., Dietz, R. and Anker, S.D.
Abstract:Increased levels of tumor necrosis factor-alpha (TNF-alpha) correlate with poor prognoses in chronic heart failure (CHF). This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion. The beta-blocker bisoprolol abolishes this effect.
Keywords:Adrenergic and beta Receptors, Adrenergic beta-Antagonists, Bisoprolol, Cardiovascular Agents, Heart Failure, Isoproterenol, Lipopolysaccharides, Norepinephrine, Tumor Necrosis Factor-alpha
Source:American Journal of Cardiology
ISSN:0002-9149
Volume:95
Page Range:885-889
Date:1 January 2005
Official Publication:https://doi.org/10.1016/j.amjcard.2004.12.022
PubMed:View item in PubMed

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