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Quantitative RT-PCR of Wilms tumor gene transcripts (WT1) for the molecular monitoring of patients with accelerated phase bcr/abl + CML

Item Type:Article
Title:Quantitative RT-PCR of Wilms tumor gene transcripts (WT1) for the molecular monitoring of patients with accelerated phase bcr/abl + CML
Creators Name:Na, I.K. and Kreuzer, K.A. and Lupberger, J. and Doerken, B. and Coutre, P.
Abstract:The tyrosine kinase inhibitor imatinib inhibits the activity of the bcr/abl fusion protein present in patients with chronic myeloid leukemia. Although in chronic phase patients response to therapy can be monitored by quantitative RT-PCR for bcr/abl mRNA transcripts, in advanced disease (accelerated phase or blast crisis) only few patients respond on a molecular level. We investigated Wilms tumor gene (WT1) and bcr/abl mRNA transcripts in 16 accelerated phase CML patients by quantitative real time PCR. In contrast to the bcr/abl mRNA levels the WT1 mRNA levels were indicative for hematologic relapse (n = 6) versus response (n = 10).
Keywords:Wilms Tumor Gene 1 (WT1), CML, Imatinib, Accelerated Phase, Quantitative RT-PCR
Source:Leukemia Research Reports
ISSN:2213-0489
Publisher:Elsevier (The Netherlands)
Volume:29
Number:3
Page Range:343-345
Date:1 March 2005
Official Publication:https://doi.org/10.1016/j.leukres.2004.08.003
PubMed:View item in PubMed

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