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Association of the HLA region with multiple sclerosis as confirmed by a genome screen using >10,000 SNPs on DNA chips

Item Type:Article
Title:Association of the HLA region with multiple sclerosis as confirmed by a genome screen using >10,000 SNPs on DNA chips
Creators Name:Goedde, R. and Rohde, K. and Becker, C. and Toliat, M. and Entz, P. and Suk, A. and Mueller, N. and Sindern, E. and Haupts, M. and Schimrigk, S. and Nuernberg, P. and Epplen, J.
Abstract:Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, with a complex genetic background. Here, we present a genome screen for association in small scale, employing 11,555 single nucleotide polymorphisms (SNPs) on DNA chips for genotyping 100 MS patients stratified for HLA-DR2 + and 100 controls. More than 500 SNPs revealed significant differences between cases and controls before Bonferroni correction. A fraction of these SNPs was reanalysed in two additional cohorts of patients and controls, using high-throughput genotyping methods. A marker on chromosome 6p21.32 (rs2395182) yielded the highest significance level, validating the established HLA-DR association.
Keywords:Genetic Markers, Genetic Screening, Genome, HLA-DR Antigens, HLA-DR2 Antigen, Linkage, Multiple Sclerosis, Oligonucleotide Array Sequence Analysis, Single Nucleotide Polymorphism
Source:Journal of Molecular Medicine
ISSN:0946-2716
Publisher:Springer (Germany)
Volume:83
Number:6
Page Range:486-494
Date:1 January 2005
Official Publication:https://doi.org/10.1007/s00109-005-0650-8
PubMed:View item in PubMed

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