Helmholtz Gemeinschaft


p75NTR - live or let die

Item Type:Review
Title:p75NTR - live or let die
Creators Name:Nykjaer, A. and Willnow, T.E. and Petersen, C.M.
Abstract:During neuronal development, neurotrophins are essential factors that promote survival, differentiation and myelination of neurons. The trophic signals are relayed to the cells via binding to Trk receptor tyrosine kinases and the p75 neurotrophin receptor. Paradoxically, the p75 neurotrophin receptor also ensures rapid and appropriate apoptosis of neonatal neurons not reaching their proper targets and transmits death signals to injured neurons. Until recently, the mechanisms by which the p75 neurotrophin receptor governs these opposing functions have remained elusive. By the identification of new ligands and cytosolic interacting partners, receptor cleavage products and coreceptors, some of these mechanisms are now being unraveled. Here, we review recent progress in delineating the molecular networks that enable p75NTR to dictate life and death.
Keywords:Cell Death, Cell Survival, Receptor Protein-Tyrosine Kinases, Nerve Growth Factor Receptor, Nerve Growth Factor Receptors, Signal Transduction, Animals
Source:Current Opinion in Neurobiology
Page Range:49-57
Date:1 January 2005
Official Publication:https://doi.org/10.1016/j.conb.2005.01.004
PubMed:View item in PubMed

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