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Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast

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Official URL:https://doi.org/10.1083/jcb.200410030
PubMed:View item in PubMed
Creators Name:Dimmer, K.S. and Jakobs, S. and Vogel, F. and Altmann, K. and Westermann, B.
Journal Title:Journal of Cell Biology
Journal Abbreviation:J Cell Biol
Volume:168
Number:1
Page Range:103-115
Date:3 January 2005
Keywords:AAC, ADP/ATP Carrier, mtDNA, Mitochondrial DNA, mtGFP, Mitochondria-Targeted GFP, PK, Proteinase K
Abstract:The MDM31 and MDM32 genes are required for normal distribution and morphology of mitochondria in the yeast Saccharomyces cerevisiae. They encode two related proteins located in distinct protein complexes in the mitochondrial inner membrane. Cells lacking Mdm31 and Mdm32 harbor giant spherical mitochondria with highly aberrant internal structure. Mitochondrial DNA (mtDNA) is instable in the mutants, mtDNA nucleoids are disorganized, and their association with Mmm1-containing complexes in the outer membrane is abolished. Mutant mitochondria are largely immotile, resulting in a mitochondrial inheritance defect. Deletion of either one of the MDM31 and MDM32 genes is synthetically lethal with deletion of either one of the MMM1, MMM2, MDM10, and MDM12 genes, which encode outer membrane proteins involved in mitochondrial morphogenesis and mtDNA inheritance. We propose that Mdm31 and Mdm32 cooperate with Mmm1, Mmm2, Mdm10, and Mdm12 in maintenance of mitochondrial morphology and mtDNA.
ISSN:0021-9525
Publisher:Rockefeller University Press (U.S.A.)
Additional Information:Copyright (c) 2005 by The Rockefeller University Press
Item Type:Article

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