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SMART 4.0: towards genomic data integration

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Item Type:Article
Title:SMART 4.0: towards genomic data integration
Creators Name:Letunic, I. and Copley, R.R. and Schmidt, S. and Ciccarelli, F.D. and Doerks, T. and Schultz, J. and Ponting, C.P. and Bork, P.
Abstract:SMART (Simple Modular Architecture Research Tool) is a web tool (http://smart.embl.de/) for the identification and annotation of protein domains, and provides a platform for the comparative study of complex domain architectures in genes and proteins. The January 2004 release of SMART contains 685 protein domains. New developments in SMART are centred on the integration of data from completed metazoan genomes. SMART now uses predicted proteins from complete genomes in its source sequence databases, and integrates these with predictions of orthology. New visualization tools have been developed to allow analysis of gene intron-exon structure within the context of protein domain structure, and to align these displays to provide schematic comparisons of orthologous genes, or multiple transcripts from the same gene. Other improvements include the ability to query SMART by Gene Ontology terms, improved structure database searching and batch retrieval of multiple entries.
Keywords:Algorithms, Computational Biology, Protein Databases, Genome, Genomics, Internet, Introns, Tertiary Protein Structure, Proteins, Proteome, Proteomics, Sequence Alignment, Software, Animals
Source:Nucleic Acids Research
Publisher:Oxford University Press
Number:Database Issue
Page Range:D142-D144
Date:1 January 2004
Official Publication:https://doi.org/10.1093/nar/gkh088
PubMed:View item in PubMed

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