Cytochrome P450 biosensors - a review

Item Type:	Review
Title:	Cytochrome P450 biosensors - a review
Creators Name:	Bistolas, N. and Wollenberger, U. and Jung, C. and Scheller, F.W.
Abstract:	Cytochrome P450 (CYP) is a large family of enzymes containing heme as the active site. Since their discovery and the elucidation of their structure, they have attracted the interest of scientist for many years, particularly due to their catalytic abilities. Since the late 1970s attempts have concentrated on the construction and development of electrochemical sensors. Although sensors based on mediated electron transfer have also been constructed, the direct electron transfer approach has attracted most of the interest. This has enabled the investigation of the electrochemical properties of the various isoforms of CYP. Furthermore, CYP utilized to construct biosensors for the determination of substrates important in environmental monitoring, pharmaceutical industry and clinical practice.
Keywords:	Bioelectrocatalysis, Cytochrome P450, Electrochemistry, Modified electrodes
Source:	Biosensors and Bioelectronics
ISSN:	0956-5663
Publisher:	Elsevier Advaced Technology
Volume:	20
Number:	12
Page Range:	2408-2423
Date:	1 January 2005
Official Publication:	https://doi.org/10.1016/j.bios.2004.11.023
PubMed:	View item in PubMed

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