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The role of tumor stroma in the interaction between tumor and immune system

Item Type:Review
Title:The role of tumor stroma in the interaction between tumor and immune system
Creators Name:Blankenstein, T.
Abstract:It is often assumed that tumor rejection is mainly the result of cytotoxic T lymphocytes (CTLs) killing the tumor cells. However, recent studies have demonstrated that the rejection process is not as simple as this. In some models, tumors are rejected in the absence of lytic mechanisms (e.g. perforin or Fas ligand), and in others CTLs kill tumor stromal cells that cross-present antigen. T cells with lytic function but IFN-γ deficiency rarely reject tumors. IFN-γ and, in some models, other T-cell cytokines such as TNF-α, IL-4 or IL-10 contribute to tumor rejection by inhibition of tumor stroma formation. These cytokines inhibit tumor-induced angiogenesis, probably through different cellular targets.
Keywords:CD8-Positive T-Lymphocytes, Cross-Priming, Immune System, Interleukin-10, Interleukin-4, Neoplasm Antigens, Neoplasms, Stromal Cells, Tumor Necrosis Factor-alpha, Animals
Source:Current Opinion in Immunology
Publisher:Current Biology
Page Range:180-186
Date:1 January 2005
Official Publication:https://doi.org/10.1016/j.coi.2005.01.008
PubMed:View item in PubMed

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