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A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics

Official URL:https://doi.org/10.1016/j.tig.2004.11.008
PubMed:View item in PubMed
Creators Name:Ivics, Z. and Izsvak, Z.
Journal Title:Trends in Genetics
Journal Abbreviation:Trends Genet
Page Range:8-11
Date:1 January 2005
Keywords:DNA Transposable Elements, Genomics, Molecular Evolution, Vertebrates
Abstract:Genome sequences of vertebrate model organisms are becoming available, fuelling the next challenging phase of research: annotating all of the genes with functional information. The functional annotation of all of the ∼35 000 genes in mammals will undoubtedly require complementing the technologies of forward and reverse genetics in mutagenesis screens. Two recent articles report on the construction of retrotransposable elements that efficiently 'jump' in mammalian cells. These new elements hold great promise as useful vectors for insertional mutagenesis screens in the mouse.
Publisher:Elsevier (The Netherlands)
Item Type:Article

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