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A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics

Item Type:Article
Title:A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics
Creators Name:Ivics, Z. and Izsvak, Z.
Abstract:Genome sequences of vertebrate model organisms are becoming available, fuelling the next challenging phase of research: annotating all of the genes with functional information. The functional annotation of all of the ∼35 000 genes in mammals will undoubtedly require complementing the technologies of forward and reverse genetics in mutagenesis screens. Two recent articles report on the construction of retrotransposable elements that efficiently 'jump' in mammalian cells. These new elements hold great promise as useful vectors for insertional mutagenesis screens in the mouse.
Keywords:DNA Transposable Elements, Genomics, Molecular Evolution, Vertebrates
Source:Trends in Genetics
ISSN:0168-9525
Publisher:Elsevier (The Netherlands)
Volume:21
Number:1
Page Range:8-11
Date:1 January 2005
Official Publication:https://doi.org/10.1016/j.tig.2004.11.008
PubMed:View item in PubMed

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