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Activating auto-antibodies against the AT1 receptor in preeclampsia

Item Type:Article
Title:Activating auto-antibodies against the AT1 receptor in preeclampsia
Creators Name:Dechend, R. and Mueller, D.N. and Wallukat, G. and Homuth, V. and Krause, M. and Dudenhausen, J. and Luft, F.C.
Abstract:Immune mechanisms have been shown to be important in the pathogenesis of preeclampsia. Here, we review our studies of agonistic antibodies against the AT1 receptor in the pathogenesis as well as a pathologic phenotype of this disorder, focusing on observations in our laboratory. We have demonstrated their specificity of the binding by Western blotting, co-localization, and co-immunoprecipitation experiments. AT1-AA induce signaling in vascular cells and trophoblasts including AP-1 and nuclear factor-kappaB (NF-κB) activation. The signaling results in tissue factor production and reactive oxygen species (ROS) generation, both of which have been implicated in preeclampsia. The role of AT1-AA in preeclampsia and other severe hypertensive conditions has not yet been proven with certainty. However, we believe the findings are compelling and warrant further study.
Keywords:Agonistic Autoantibodies, Angiotensin, Preeclampsia, Reactive Oxygen Species, Tissue Factor, Animals, Rats
Source:Autoimmunity Reviews
Page Range:61-65
Date:1 January 2005
PubMed:View item in PubMed

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