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Paracrine role for periadventitial adipose tissue in the regulation of arterial tone

Official URL:https://doi.org/10.1016/j.tips.2004.10.005
PubMed:View item in PubMed
Creators Name:Gollasch, M. and Dubrovska, G.
Journal Title:Trends in Pharmacological Sciences
Journal Abbreviation:Trends Pharmacol Sci
Volume:25
Page Range:647-653
Date:1 December 2004
Keywords:Adipose Tissue, Arteries, Arteriosclerosis, Hypertension, Intercellular Signaling Peptides and Proteins, Obesity, Paracrine Communication, Potassium Channels, Smooth and Vascular Muscle, Vascular Endothelium
Abstract:Recent studies propose a paracrine role for periadventitial adipose tissue in the regulation of vascular tone. This regulation depends on the anatomical integrity of the periadventitial adipose tissue and involves adipocyte-derived relaxing factor (ADRF). Although the nature of ADRF is largely unknown, it is released by periadventitial adipocytes and induces vasorelaxation by opening K+ channels in the plasma membrane of smooth muscle cells. Alterations in the paracrine role of periadventitial adipose tissue might have a role in vascular dysfunction in hypertension and metabolic disease. Therefore, understanding alterations in ADRF release and the K+ channels involved will help further our understanding of the increased cardiovascular risk and development of chronic vascular disease in obesity. Furthermore, ADRF and perhaps its putative targets might represent exciting new targets for the development of drugs to treat cardiovascular disorders.
ISSN:0165-6147
Item Type:Review

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