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Paracrine role for periadventitial adipose tissue in the regulation of arterial tone

Item Type:Review
Title:Paracrine role for periadventitial adipose tissue in the regulation of arterial tone
Creators Name:Gollasch, M. and Dubrovska, G.
Abstract:Recent studies propose a paracrine role for periadventitial adipose tissue in the regulation of vascular tone. This regulation depends on the anatomical integrity of the periadventitial adipose tissue and involves adipocyte-derived relaxing factor (ADRF). Although the nature of ADRF is largely unknown, it is released by periadventitial adipocytes and induces vasorelaxation by opening K+ channels in the plasma membrane of smooth muscle cells. Alterations in the paracrine role of periadventitial adipose tissue might have a role in vascular dysfunction in hypertension and metabolic disease. Therefore, understanding alterations in ADRF release and the K+ channels involved will help further our understanding of the increased cardiovascular risk and development of chronic vascular disease in obesity. Furthermore, ADRF and perhaps its putative targets might represent exciting new targets for the development of drugs to treat cardiovascular disorders.
Keywords:Adipose Tissue, Arteries, Arteriosclerosis, Hypertension, Intercellular Signaling Peptides and Proteins, Obesity, Paracrine Communication, Potassium Channels, Smooth and Vascular Muscle, Vascular Endothelium
Source:Trends in Pharmacological Sciences
ISSN:0165-6147
Volume:25
Page Range:647-653
Date:1 December 2004
Official Publication:https://doi.org/10.1016/j.tips.2004.10.005
PubMed:View item in PubMed

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